Ross Lab



The Delta-Opioid Receptor Bidirectionally Modulates Itch

Kelly M Smith, Eileen K Nguyen, Sarah E Ross                                                                                                            Year: 2023 • The Journal of Pain. 24(2)264-272  Download Article


Organization of Cortical and Thalamic Input to Inhibitory Neurons in Mouse Motor Cortex

Sandra U Okoro, Roman U Goz, Bridget W Njeri, Madhumita Harish, Catherine F Ruff, Sarah E Ross, Charles Gerfen, Bryan M Hooks

Year: 2022 • The Journal of Neuroscience. 42(43)8095-8112  Download Article


Cell Type-specific Calcium Imaging of Central Sensitization in Mouse Dorsal Horn

Charles Warwick, Joseph Salsovic, Junichi Hachisuka, Kelly M. Smith, Tayler D. Sheahan, Haichao Chen, James Ibinson, H. Richard Koerber, Sarah E. Ross 

Year: 2022 • Nat Commun. 3:13:(5199)  Download Article


Medullary Kappa-opioid Receptor Neurons Inhibit Pain and Itch through a Descending Circuit

Eileen K Nguyen, Kelly M. Smith, Nathan Cramer, Ruby A Holland, Isabel H Bleimeister, Krystal Flores-Felix, Hanna Silberberg, Asaf Keller, Claire E Le Pichon, Sarah E Ross 

Year: 2022 • Brain 145(7): (2586-2601)  Download Article


Mechanical Allodynia Circuitry in the Dorsal Horn Is Defined by the Nature of the Injury

Cedric Peirs, Sean-Paul G. Williams, Xinyi Zhao, Cynthia M. Arokiaraj, David W. Ferreira, Myung-chul Noh, Kelly M. Smith, Priyabrata Halder, Kelly A. Corrigan, Jeremy Y. Gedeon, Suh Jin Lee, Graziana Gatto, David Chi, Sarah E. Ross, Martyn Goulding, Rebecca P Seal 

Year: 2021 • Neuron 109(1):73-90   Download Article

pain2022 ch

MrgprdCre Lineage Neurons Mediate Optogenetic Allodynia through An Emergent Polysynaptic Circuit  Charles Warwick, Colleen Cassidy, Junichi Hachisuka, Margaret C Wright, Kyle M Baumbauer, Peter C Adelman, Kuan H Lee, Kelly M smith, Tayler D Sheahan, Sarah E Ross, H Richard Koerber

Year: 2021 • Pain 162 21(2120-21310)  Download Article


Morphine Acts on Spinal Dynorphin Neurons to Cause Itch Through Disinhibition

Eileen K Nguyen, Grace Lim, Huiping Ding, Junichi Hachisuka,  Mei-Chuan Ko, Sarah E Ross

Year: 2021 • Sci Transl Med 13(579):eabc3774  Download Article

Figure 3

Mechanistic Insights into Spinal Neurones Involved in Neuraxial Opioid-induced Pruritus
Eileen K Nguyen, Grace Lim, Sarah E Ross

Year: 2021 • British Journal of Anaesthesia 126(5):e179-e181   Download Article


Parallel Ascending Spinal Pathways for Affective Touch and Pain

Seungwon Choi, Junichi Hachisuka, Matthew A Brett, Alexandra Magee, Yu Omori, Noor-ul-Aine Iqbal, Dawei Zhang, Michelle M DeLisle, Rachel L Wolfson, Ling Bai, Celine Santiago, Shiaoching Gong, Martyn Goulding, Nathaniel Heintz, H Richard Koerber, Sarah E Ross, David D Ginty

Year: 2020 • Nature 1587(7833): 258–263  Download Article


The Neurokinin-1 Receptor is Expressed with Gastrin Releasing Peptide Receptor in Spinal Interneurons 

  • and Modulates Itch

Tayler D Sheahan, Charles A Warwick, Louis G Fanien, Sarah E Ross

Year: 2020 • The Journal of Neuroscience 40(46):8816–8830  Download Article


Divergent Neural Pathways Emanating from the Lateral Parabrachial Nucleus Mediate Distinct Components of the Pain Response
Michael C ChiangEileen K NguyenAndrew E PapaleSarah E Ross

Year: 2020 • Neuron 106 (1-13)  Download Article


Selective-cold Output through a Distinct Subset of Lamina I Spinoparabrachial Neurons
Junichi Hachisuka, H Richard Koerber, Sarah E. Ross

Year: 2020  Pain 161(1): 185-194  Download Article


Optogenetic Assessment of VIP, PV, SOM, and NOS Inhibitory Neuron Activity and Cerebral Blood Flow Regulation in Mouse Somato-sensory Cortex
Michael B Krawchuk, Catherine F Ruff, Xiaoling Yang, Sarah E Ross, Alberto L Vazquez

Year: 2019 • J Cereb Blood Flow Metabolism 40(7) (1427-1440)  Download Article


Kappa Opioid Receptor Distribution and Function in Primary Afferents
Lindsey M. Snyder, Michael C. Chiang, Emanuel Loeza-Alcocer, Yu Omori, Junichi Hachisuka, Tayler D Sheahan, Jenna R. Gale, Peter C Adelman, Elizabeth I Sypek, Stephanie A. Fulton, Robert L Friedman, Margaret C Wright, Melissa Giraldo Duque, Yeon Sun Lee, Zeyu Hu, Huizhen Huang, Xiaoyun Cai, Kimberly A Meerschaert, Vidhya Nagarajan, Toshiro Hirai, Gregory Scherrer, Daniel H Kaplan, Frank Porreca, Brian M Davis, Michael S Gold, Richard H Koerber, Sarah E Ross

Year: 2018 • Neuron Volume 99, Issue 6, P1274-1288.E6 • Download Article

See also Neuron’s Preview of our article • Download Preview


A Comparative Analysis of Rod Bipolar Cell Transcriptomes Identifies Novel Genes Implicated in Night Vision
Woods, S. M., E. Mountjoy, D. Muir, Sarah E. Ross, D. Atan

Year: 2018 • Sci Rep 8(1): 5506 • Download Article


Wind-up in lamina I Spinoparabrachial Neurons: a Role for Reverberatory Circuits
Hachisuka, J., Y. Omori, M. C. Chiang, M. S. Gold, H. R. Koerber, S. E. Ross

Year: 2018 • Pain doi: 10.1097/j.pain.0000000000001229 • Download Article


Automated Acoustic Detection of Mouse Scratching
Elliott, P., M. G’Sell, L. M. Snyder, S. E. Ross, V. Ventura

Year: 2017 • PLoS One 12(7): e0179662 • Download Article


Semi-intact ex Vivo Approach to Investigate Spinal Somatosensory Circuits
Junichi Hachisuka, Kyle M. Baumbauer, Yu Omori, Lindsey M. Snyder, H. Richard Koerber, Sarah E. Ross

Year: 2016 • eLife 2016;5:e22866 • Download Article


Generation of a NK1R-CreER Knockin Mouse Strain to Study Cells Involved in Neurokinin 1 Receptor Signaling.
Huang, H., M. S. Kuzirian, X. Cai, L. M. Snyder, J. Cohen, D. H. Kaplan, S. E. Ross

Year: 2016 • Genesis. • Download Article


Gi-DREADD Expression in Peripheral Nerves Produces Ligand-dependent Analgesia, as well as Ligand-Independent Functional Changes in Sensory Neurons
Saloman, J.L., Scheff, N.N., Snyder, L.M., Ross, S.E., Davis, B.M.*, Gold M.S.

Year: 2016 • Journal of Neuroscience, 36(42):10769-81 • Download Article


Bhlhb5::flpo allele Uncovers a Requirement for Bhlhb5 for the Development of the Dorsal Cochlear Nucleus
Cai, X., Kardon, A.P., Snyder, L.M., Kuzirian, M.S., Minestro, S., de Souza, L., Rubio, M.E., Maricich, S.M., Ross, S.E

Year: 2016 • Developmental Biology • Download Article


Generation of a KOR-Cre Knockin Mouse Strain to Study Cells Involved in Kappa Opioid Signaling
Cai, X., H. Huang, M. S. Kuzirian, L. M. Snyder, M. Matsushita, M. C. Lee, C. Ferguson, G. E. Homanics, A. L. Barth ,S. E. Ross

Year: 2016 • Genesis 54(1): 29-37 • Download Article

See also KOR-Cre expression in the brain • Supplemental Information


Keratinocytes Can Modulate and Directly Initiate Nociceptive Responses
K. M. Baumbauer, J. J. DeBerry, P. C. Adelman, R. H. Miller, J. Hachisuka, K. H. Lee, S. E. Ross, H. R. Koerber, B. M Davis, K. M. Albers

Year: 2015 •  eLIFE 10.7554/eLife.09674 • Download Article


TheTranscription Factor PRDM8 is Required for Rod Bipolar and Type 2 OFF-cone Bipolar Cell Survival and Amacrine Subtype Identity
C.C. Jung, D. Atan, D. Ng, L. Ploder, S.E. Ross, M. Klein, D. Birch, E. Diez, R.R. McInnes

Year: 2015 •  PNAS 10.1073/pnas.1505870112 • Download Article


Identification of Spinal Circuits Transmitting and Gating Mechanical Pain
B. Duan, L. Cheng, S. Bourane, O. Britz, C. Padilla, L. Garcia-Campmany, M. Krashes, W. Knowlton, T. Velasquez, X. Ren, S.E. Ross, B.B. Lowell, Y. Wang, M. Goulding, Q. Ma

Year: 2014 • Cell 159(6):1147-32 • Download Article


Transplant Restoration of Spinal Cord Inhibitory Controls Ameliorates Neuropathic Itch
J. M. Braz, D. Juarez-Salinas, S. E. Ross, A. I. Basbaum

Year: 2014 • Journal of Clinical Investigation 124(8):3612–3616 • Download Article


Dynorphin Acts as a Neuromodulator to Inhibit Itch in the Dorsal Horn of the Spinal Cord
A. P. Kardon*, E. Polgár*, J. Hachisuka, L. M. Snyder, D. Cameron, S. Savage, X. Cai, S. Karnup, C. R. Fan, G. M. Hemenway, C. S. Bernard, E. S. Schwartz, H. Nagase, C. Schwarzer, M. Watanabe, T. Furuta, T. Kaneko, H. R. Koerber, A. J. Todd**, S. E. Ross**

Year: 2014 • Neuron 82(3):573-586 • Download Article • Supplemental Information (scroll to the bottom)

See also Neuron’s Preview of our article • Download Preview


Bhlhb5 and Prdm8 form a Repressor Complex Involved in Neuronal Circuit Assembly.
S. E. Ross, A. E. McCord, C. Jung, D. Atan, S. I. Mok, M. Hemberg, T.K. Kim, J. Salogiannis, L. Hu, S. Cohen, Y. Lin, D. Harrar, R. R. McInnes, M. E. Greenberg

Year: 2012 • Neuron 73(2):292–303 • Download Article • Supplemental Information


Loss of Inhibitory Interneurons in the Dorsal Spinal Cord and Elevated Itch in Bhlhb5 Mutant Mice
S. E. Ross, A. Mardinly, A. E. McCord, J. Zurawski, S. Cohen, C. Jung, L. Hu, S. I. Mok, A. Shah, E. Savner, C. Tolias, R. Corfas, S. Chen, P. Inquimbert, Y. Xu, R. R. McInnes, F.L. Rice, Q. Ma, G. Corfas, C. Woolf, M. E. Greenberg.

Year: 2010 • Neuron 2010 25;65(6):886-98 • Download Article • Supplemental Information


Inhibition of Adipogenesis by Wnt Signaling
S. E. Ross, N. Hemati, K. A. Longo, C. N. Bennett, P. C. Lucas, R. L. Erickson, O. A. MacDougald

Year: 2000 • Science 289 • Download Article



Evaluation of Therapies for Peripheral and Neuraxial Opioid-induced Pruritus Based on Molecular and Cellular Discoveries 

Eileen K Nugyen, Grace Lim, Sarah E Ross 

Year: 2021 • Anesthesiology 135:350-365 • Download Article


Beyond Lidocaine: Selective Voltage-gated Sodium Channel Blockade for Vaginal Pain

Ruby A Holland, Sarah E Ross 

Year: 2021 • Pain 162(1):1-3 • Download Article


Making Connections: Recent Advances in Spinal Cord Dorsal Horn Circuitry

Kelly M Smith, Sarah E Ross 

Year: 2020 • Pain 161:S122-S126 • Download Article


Neuronal Diversity in the Somatosensory System: Bridging the Gap Between Cell Type and Function
Graziana Gatto, Kelly M Smith, Sarah E Ross and Martyn Goulding

Year: 2019 • Current Opinion in Neurobiology 56:167–174 • Download Article


Small RNAs, but Sizable Itch: TRPA1 Activation by an Extracellular MicroRNA
Tayler D Sheahan, Junichi Hachisuka and Sarah E Ross

Year: 2018 • Neuron 99(3): 421-422 • Download Article


Itch and Neuropathic Itch
Junichi Hachisuka, Michael C Chiang and Sarah E Ross

Year: 2018 • Pain 159(3): 603-609. • Download Article


Insight into B5-I spinal Interneurons and Their Role in the Inhibition of Itch and Pain
Michael C Chiang, Junichi Hachisuka, Andrew J Todd and Sarah E Ross

Year: 2016 • Pain 157: 544-545 • Download Article


Ensuring Transparency and Minimization of Methodologic Bias in Preclinical Pain Research: Precise Considerations
Andrews, N. A., A. Latremoliere, A. I. Basbaum, J. S. Mogil, F. Porreca, A. S. Rice, C. J. Woolf, G. L. Currie, R. H. Dworkin, J. C. Eisenach, S. Evans, J. S. Gewandter, T. D. Gover, H. Handwerker, W. Huang, S. Iyengar, M. P. Jensen, J. D. Kennedy, N. Lee, J. Levine, K. Lidster, I. Machin, M. P. McDermott, S. B. McMahon, T. J. Price, S. E. Ross, G. Scherrer, R. P. Seal, E. S. Sena, E. Silva, L. Stone, C. I. Svensson, D. C. Turk and G. Whiteside

Year: 2016 • Pain 157: 901-909 • Download Article


An Unexpected Role for TRPV4 in Serotonin-Mediated Itch
Lindsey M Snyder, Marissa S. Kuzirian and Sarah E Ross

Year: 2016 • J. of Investigative Dermatology 336: 7-9  Download Our Preview

See also the original article by Akiyama et al. • Download Article


Understanding the Switch from Pain-to-itch in Dermatitis
Junichi Hachisuka and Sarah E Ross

Year: 2014 • Neuroscience Letters 579: 188-189 • Download Our Preview

See also the original article by Fu et al. • Download Article


An SCN9A Variant, Known to Cause Pain, Is now Found to Cause Itch
Lindsey M Snyder, Sarah E Ross and Inna Belfer

Year: 2014 • Pain 155: 1677-1678 • Download Our Preview

See also the original article by Devigili et al. • Download Article


Pain and Itch: Insights into the Neural Circuits of Aversive Somatosensation in Health and Disease.
Sarah E Ross

Year: 2011 • Current Opinion in Neurobiology 21:1-8 • Download Article


Basic Helix-Loop-Helix Factors in Cortical Development
Sarah E Ross, Michael E Greenberg and Charles D Stiles

Year: 2003 • Neuron 39:13-25 • Download Article



Emerging Techniques in Basic Science and Translation
S. E. Ross, M. E. Greenberg and C. D. Michael Iadarola, PhD,Stephen B. McMahon, PhD,Sarah E. Ross, PhD, Tayler D. Sheahan, PhD,and Joost Verhaagen, PhD
Year: 2018 • Pain 2018: Refresher Courses, 17th World Congress on Pain • Download Book Chapter


Activating, Inhibiting, and Highjacking TRP Channels for Relief from Itch
S. E. Ross, M. E. Greenberg and C. D. Michael Iadarola, PhD,Stephen B. McMahon, PhD,Sarah E. Ross, L. M. Snyder, H. Huang, and S. E. Ross

Year: 2015 • TRP channels as therapeutic targets: from basic science to clinical use: 279-291 • Download Book Chapter


Itch and Its Inhibition by Counter Stimuli
L. M. Snyder and S. E. Ross

Year: 2015 • Handbook of Experimental Pharmacology 226: 191-206 • Download Book Chapter


A Counterpart to Pain: Itch
A. P. Kardon and S. E. Ross

Year: 2014 • Pain Genetics: Basic to Translational Science • Download Book Chapter


Spinal Microcircuits and the Regulation of Itch
S. E. Ross, J. Hachisuka and A. J. Todd

Year: 2014 • Itch: Mechanisms & Treatment • Download Book Chapter • Download Color Insert


Developmental Origin of PreBötzinger Complex Respiratory Neurons. J Neurosci

Gray P.A., Hayes J.A., Ling G.Y., Llona I, Tupal S, Picardo M.C., Ross S.E, Hirata T., Corbin J.G., Eugenín J., Del Negro C.A.
Year: 2010   Neurosci 3;30(44):14883-95  Download Article

Identification of Molecular Markers of Bipolar Cells in the Murine Retina

Kim, D. S., S. E. Ross, J. M. Trimarchi, J. Aach, M. E. Greenberg and C. L. Cepko
Year: 2008   Comp Neurol. 507(5): 1795-810  Download Article 

Stress-dependent Regulation of FOXO Transcription Factors by the SIRT1 Deacetylase

Brunet, A., Sweeney, L. B., Sturgill, J. F., Chua, K. F., Greer, P. L., Lin, Y., Tran, H., Ross, S. E., Mostoslavsky, R., Cohen, H. Y., Hu, L. S., Cheng, H. L., Jedrychowski, M. P., Gygi, S. P., Sinclair, D. A., Alt, F. W., Greenberg, M. E.
Year: 2004 • Science 303:2011-5   Download Article 

Phosphorylation of C/EBPalpha Inhibits Granulopoiesis

Ross, S.E.*, Radomska*, H. S., Wu, B., Zhang, P., Winnay, J. N., Bajnok, L., Wright, W. S., Schaufele, F., Tenen, D. G., MacDougald, O. A

  •             Year: 2003 • Mol Cell Biol 24: 675-86  • Download Article

Wnt signaling Protects 3T3-L1 Preadipocytes from Apoptosis Through Induction of Insulin-like Growth Factors

Longo K. A., Kennell J. A., Ochocinska M. J., Ross S. E., Wright W. S., MacDougald O. A.
Year: 2002 J Biol Chem 277: 38239-44 • Download Article

Regulation of Wnt Signaling during Adipogenesis

Bennett C. N., Ross S. E., Longo K. A., Bajnok L., Hemati N., Johnson K. W., Harrison S. D., MacDougald O. A.
Year: 2002  J Biol Chem 277: 30998-004  Download Article 

Microarray Analyses during Adipogenesis: Understanding the Effects of Wnt Signaling on Adipogenesis and the Roles of Liver X Receptor a in Adipocyte Metabolism

Ross S. E., Erickson R. L, Gerin I., DeRose P. M., Bajnok L., Longo K. A., Misek D. E., Kuick R., Hanash S. M., Atkins K. B., Andresen S.M., Nebb H. I., Madsen L., Kristiansen K., MacDougald O. A.
Year: 2002 Mol Cell Biol 22:5989-99 • Download Article 

Growth Hormone Regulates Phosphorylation and Function of CCAAT/enhancer-binding Protein by Modulating Akt and glycogen Synthase Kinase-3

           Piwien-Pilipuk, G., D. V. Mater, S. E. Ross, O. A. MacDougald and J. Schwartz

Year: 2001 J Biol Chem 276:16348-55  Download Article 

P300 Coactivates the Adipogenic Transcription Factor C/EBPα

Erickson, R. L., N. Hemati, S. E. Ross, and O. A. MacDougald.
Year: 2001 J Biol Chem 276(22): 19664-71  Download Article

Glycogen synthase kinase 3 is an insulin-regulated C/EBPα kinase

Ross, S. E., R. L. Erickson, N. Hemati, and O. A. MacDougald
Year: 1999 Mol Cell Biol 19: 8433-41  Download Article 

CCAAT/enhancer-binding Protein Beta (C/EBPβ) and C/EBPδ Contribute to Growth Hormone-regulated Transcription of c-fos

Liao, J., G. Piwien-Pilipuk, S. E. Ross, C. L. Hodge, L. Sealy, O. A. MacDougald, and J. Schwartz
Year: 1999 J Biol Chem 274:31597-604   Download Article 

The role of C/EBP genes in adipocyte differentiation

Darlington, G. J., S. E. Ross, and O. A. MacDougald
Year: 1998 J Biol Chem 273:30057-60  Download Article 

A Role for the p38 Mitogen-activated Protein Kinase/Hsp 27 Pathway in Cholecystokinin-induced Changes in the Actin Cytoskeleton in rat Pancreatic Acini

Schafer, C., S. E. Ross, M. J. Bragado, G. E. Groblewski, S. A. Ernst, and J. A. Williams
Year: 1998 J Biol Chem 273: 24173-80   Download Article 

Signaling Pathways through Which Insulin Regulates CCAAT/enhancer Binding Protein Alpha (C/EBPα) Phosphorylation and Gene Expression in 3T3-L1 Adipocytes. Correlation with GLUT4 Gene Expression

Hemati, N., S. E. Ross, R. L. Erickson, G. E. Groblewski, and O. A. MacDougald
Year: 1997  J Biol Chem 272:25913-9   Download Article