Ross Lab

Publications (old)

Key Publications:

The Neurokinin-1 Receptor is Expressed with Gastrin Releasing Peptide Receptor in Spinal Interneurons and Modulates Itch
Tayler D Sheahan, Charles A Warwick, Louis G Fanien, Sarah E Ross
Year: 2020 • The Journal of Neuroscience 40(46):8816–8830 • Download Article


Divergent neural pathways emanating from the lateral parabrachial nucleus mediate distinct components of the pain response
Michael C Chiang, Eileen K Nguyen, Andrew E Papale, Sarah E Ross
Year: 2020 • Neuron 106 (1-13) • Download Article


Selective-cold output through a distinct subset of lamina I spinoparabrachial neurons
Junichi Hachisuka, H. Richard Koerber and Sarah E. Ross
Year: 2020.  Pain 161(1): 185-194• Download Article


Optogenetic assessment of VIP, PV, SOM, and NOS inhibitory neuron activity and cerebral bllod flow regulation in mouse somato-sensory cortex
Krawchuk, M. B., C. F. Ruff, X. Yang, S. E. Ross and A. L. Vazquez
Year: 2019. J Cereb Blood Flow Metabolism 0(0) 1-14 • Download Article


Kappa Opioid Receptor Distribution and Function in Primary Afferents
Lindsey M. Snyder, Michael C. Chiang, Emanuel Loeza-Alcocer, Yu Omori, Junichi Hachisuka, Tayler D. Sheahan, Jenna R. Gale, Peter C. Adelman, Elizabeth I. Sypek, Stephanie A. Fulton, Robert L. Friedman, Margaret C. Wright, Melissa Giraldo Duque, Yeon Sun Lee, Zeyu Hu, Huizhen Huang, Xiaoyun Cai, Kimberly A. Meerschaert, Vidhya Nagarajan, Toshiro Hirai, Gregory Scherrer, Daniel H. Kaplan, Frank Porreca, Brian M. Davis, Michael S. Gold, Richard H. Koerber, Sarah E. Ross
Year: 2018 • Neuron Volume 99, Issue 6, P1274-1288.E6 • Download Article
See also Neuron’s Preview of our article • Download Preview


A comparative analysis of rod bipolar cell transcriptomes identifies novel genes implicated in night vision
Woods, S. M., E. Mountjoy, D. Muir, S. E. Ross and D. Atan
Year: 2018 • Sci Rep 8(1): 5506 • Download Article


Wind-up in lamina I spinoparabrachial neurons: a role for reverberatory circuits
Hachisuka, J., Y. Omori, M. C. Chiang, M. S. Gold, H. R. Koerber and S. E. Ross
Year: 2018 • Pain doi: 10.1097/j.pain.0000000000001229 • Download Article


Automated acoustic detection of mouse scratching
Elliott, P., M. G’Sell, L. M. Snyder, S. E. Ross and V. Ventura
Year: 2017 • PLoS One 12(7): e0179662 • Download Article


Semi-intact ex vivo approach to investigate spinal somatosensory circuits
Junichi Hachisuka, Kyle M. Baumbauer, Yu Omori, Lindsey M. Snyder, H. Richard Koerber and Sarah E. Ross
Year: 2016 • eLife 2016;5:e22866 Download Article


Generation of a NK1R-CreER Knockin Mouse Strain to Study Cells Involved in Neurokinin 1 Receptor Signaling.
Huang, H., M. S. Kuzirian, X. Cai, L. M. Snyder, J. Cohen, D. H. Kaplan and S. E. Ross
Year: 2016 • Genesis. Download Article


screen-shot-2016-10-28-at-10-30-47-amGi-DREADD expression in peripheral nerves produces ligand-dependent analgesia, as well as ligand-independent functional changes in sensory neurons
Saloman, J.L., Scheff, N.N., Snyder, L.M., Ross, S.E., Davis, B.M.*, and Gold M.S.
Year: 2016 • Journal of Neuroscience, 36(42):10769-81 Download Article


Bhlhb5::flpo allele uncovers a requirement for Bhlhb5 for the development of the dorsal cochlear nucleus
Cai, X., Kardon, A.P., Snyder, L.M., Kuzirian, M.S., Minestro, S., de Souza, L., Rubio, M.E., Maricich, S.M., and Ross, S.E
Year: 2016 •  Developmental Biology • Download Article


Generation of a KOR-Cre knockin mouse strain to study cells involved in kappa opioid signaling
Cai, X., H. Huang, M. S. Kuzirian, L. M. Snyder, M. Matsushita, M. C. Lee, C. Ferguson, G. E. Homanics, A. L. Barth and S. E. Ross
Year: 2016 •  Genesis 54(1): 29-37 • Download Article
See also KOR-Cre expression in the brain • Supplemental Information


ThumbKeratinocytes can modulate and directly initiate nociceptive responses
K. M. Baumbauer, J. J. DeBerry, P. C. Adelman, R. H. Miller, J. Hachisuka, K. H. Lee, S. E. Ross, H. R. Koerber, B. M Davis, and K. M. Albers
Year: 2015 •  eLIFE 10.7554/eLife.09674 • Download Article


ThumbThe transcription factor PRDM8 is required for rod bipolar and type 2 OFF-cone bipolar cell survival and amacrine subtype identity
C.C. Jung, D. Atan, D. Ng, L. Ploder, S.E. Ross, M. Klein, D. Birch, E. Diez, and R.R. McInnes
Year: 2015 •  PNAS 10.1073/pnas.1505870112 • Download Article


ThumbIdentification of spinal circuits transmitting and gating mechanical pain
B. Duan, L. Cheng, S. Bourane, O. Britz, C. Padilla, L. Garcia-Campmany, M. Krashes, W. Knowlton, T. Velasquez, X. Ren, S.E. Ross, B.B. Lowell, Y. Wang, M. Goulding, and Q. Ma
Year: 2014 •  Cell 159(6):1147-32Download Article


ThumbTransplant restoration of spinal cord inhibitory controls ameliorates neuropathic itch
J. M. Braz, D. Juarez-Salinas, S. E. Ross, and A. I. Basbaum
Year: 2014 • Journal of Clinical Investigation 124(8):3612–3616Download Article


ThumbDynorphin acts as a neuromodulator to inhibit itch in the dorsal horn of the spinal cord
A. P. Kardon*, E. Polgár*, J. Hachisuka, L. M. Snyder, D. Cameron, S. Savage, X. Cai, S. Karnup, C. R. Fan, G. M. Hemenway, C. S. Bernard, E. S. Schwartz, H. Nagase, C. Schwarzer, M. Watanabe, T. Furuta, T. Kaneko, H. R. Koerber, A. J. Todd**, and S. E. Ross**
Year: 2014 • Neuron 82(3):573-586Download ArticleSupplemental Information (scroll to the bottom)
See also Neuron’s Preview of our article • Download Preview


ThumbBhlhb5 and Prdm8 form a repressor complex involved in neuronal circuit assembly.
S. E. Ross, A. E. McCord, C. Jung, D. Atan, S. I. Mok, M. Hemberg, T.K. Kim, J. Salogiannis, L. Hu, S. Cohen, Y. Lin, D. Harrar, R. R. McInnes, and M. E. Greenberg
Year: 2012 • Neuron 73(2):292–303Download ArticleSupplemental Information


ThumbLoss of Inhibitory Interneurons in the Dorsal Spinal Cord and Elevated Itch in Bhlhb5 Mutant Mice
S. E. Ross, A. Mardinly, A. E. McCord, J. Zurawski, S. Cohen, C. Jung, L. Hu, S. I. Mok, A. Shah, E. Savner, C. Tolias, R. Corfas, S. Chen, P. Inquimbert, Y. Xu, R. R. McInnes, F.L. Rice, Q. Ma, G. Corfas, C. Woolf and M. E. Greenberg.
Year: 2010 • Neuron 2010 25;65(6):886-98Download ArticleSupplemental Information


ThumbInhibition of Adipogenesis by Wnt Signaling
S. E. Ross, N. Hemati, K. A. Longo, C. N. Bennett, P. C. Lucas, R. L. Erickson, O. A. MacDougald
Year: 2000 • Science 289Download Article


Previews & Reviews

Neuronal diversity in the somatosensory system: bridging the gap between cell type and function
Graziana Gatto, Kelly Megan Smith, Sarah Elizabeth Ross and Martyn Goulding
Year: 2019 • Current Opinion in Neurobiology 2019, 56:167–174 • Download Article


Small RNAs, but Sizable Itch: TRPA1 Activation by an Extracellular MicroRNA
Sheahan, T. D., J. Hachisuka and S. E. Ross
Year: 2018 • Neuron 99(3): 421-422 • Download Article


Itch and neuropathic itch
Hachisuka, J., M. C. Chiang and S. E. Ross
Year: 2018 • Pain 159(3): 603-609. • Download Article


pubpicInsight into B5-I spinal interneurons and their role in the inhibition of itch and pain
Chiang, M. C., J. Hachisuka, A. J. Todd and S. E. Ross
Year: 2016 • PAIN, in press • Download Article


pubpic2Ensuring transparency and minimization of methodologic bias in preclinical pain research: Pprecise considerations
Andrews, N. A., A. Latremoliere, A. I. Basbaum, J. S. Mogil, F. Porreca, A. S. Rice, C. J. Woolf, G. L. Currie, R. H. Dworkin, J. C. Eisenach, S. Evans, J. S. Gewandter, T. D. Gover, H. Handwerker, W. Huang, S. Iyengar, M. P. Jensen, J. D. Kennedy, N. Lee, J. Levine, K. Lidster, I. Machin, M. P. McDermott, S. B. McMahon, T. J. Price, S. E. Ross, G. Scherrer, R. P. Seal, E. S. Sena, E. Silva, L. Stone, C. I. Svensson, D. C. Turk and G. Whiteside
Year: 2016 • PAIN, in press • Download Article


pubpic3An Unexpected Role for TRPV4 in Serotonin-Mediated Itch
Snyder, L. M., M. S. Kuzirian and S. E. Ross
Year: 2016 • Download Our Preview
See also the original article by Akiyama et al. • Download Article


ThumbUnderstanding the Switch from pain-to-itch in dermatitis
J. Hachisuka and S. E. Ross
Year: 2014 • Download Our Preview
See also the original article by Fu et al. • Download Article


ThumbAn SCN9A variant, known to cause pain, is now found to cause itch
L. M. Snyder, I. Belfer, and S. E. Ross
Year: 2014 • Pain • Download Our Preview
See also the original article by Devigili et al. • Download Article


ThumbPain and itch: insights into the neural circuits of aversive somatosensation in health and disease.
S. E. Ross
Year: 2011 • Current Opinion in Neurobiology 21:1-8Download Article


ThumbBasic Helix-Loop-Helix Factors in Cortical Development
S. E. Ross, M. E. Greenberg and C. D. Stiles
Year: 2003 • Neuron 39:13-25Download Article


Book Chapters

Emerging Techniques in Basic Science and Translation
S. E. Ross, M. E. Greenberg and C. D. Michael Iadarola, PhD,Stephen B. McMahon, PhD,Sarah E. Ross, PhD, Tayler D. Sheahan, PhD,and Joost Verhaagen, PhD
Year: 2018 • Pain 2018: Refresher Courses, 17th World Congress on Pain • Download Book Chapter



Activating, inhibiting, and highjacking TRP channels for relief from itch
S. E. Ross, M. E. Greenberg and C. D. Michael Iadarola, PhD,Stephen B. McMahon, PhD,Sarah E. Ross, L. M. Snyder, H. Huang, and S. E. Ross
Year: 2015 • TRP channels as therapeutic targets: from basic science to clinical use: 279-291Download Book Chapter


ThumbItch and its inhibition by counter stimuli
L. M. Snyder and S. E. Ross
Year: 2015 • Handbook of Experimental Pharmacology 226: 191-206Download Book Chapter


ThumbA Counterpart to Pain: Itch
A. P. Kardon and S. E. Ross
Year: 2014 • Pain Genetics: Basic to Translational ScienceDownload Book Chapter


ThumbSpinal Microcircuits and the Regulation of Itch
S. E. Ross, J. Hachisuka and A. J. Todd
Year: 2014 • Itch: Mechanisms & TreatmentDownload Book ChapterDownload Color Insert


Other Publications

Developmental origin of preBötzinger complex respiratory neurons. J Neurosci

Gray P.A., Hayes J.A., Ling G.Y., Llona I, Tupal S, Picardo M.C., Ross S.E, Hirata T., Corbin J.G., Eugenín J., Del Negro C.A.
Year: 2010 • J Neurosci 3;30(44):14883-95


Identification of molecular markers of bipolar cells in the murine retina

Kim, D. S., S. E. Ross, J. M. Trimarchi, J. Aach, M. E. Greenberg and C. L. Cepko
Year: 2008 • J Comp. Neurol. 507(5): 1795-810


Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase

Brunet, A., Sweeney, L. B., Sturgill, J. F., Chua, K. F., Greer, P. L., Lin, Y., Tran, H., Ross, S. E., Mostoslavsky, R., Cohen, H. Y., Hu, L. S., Cheng, H. L., Jedrychowski, M. P., Gygi, S. P., Sinclair, D. A., Alt, F. W., Greenberg, M. E.
Year: 2004 • Science 303:2011-5


Phosphorylation of C/EBPalpha inhibits granulopoiesis

Ross, S.E.*, Radomska*, H. S., Wu, B., Zhang, P., Winnay, J. N., Bajnok, L., Wright, W. S., Schaufele, F., Tenen, D. G., MacDougald, O. A
Year: 2003 • Mol Cell Biol 24:675-86


Wnt signaling protects 3T3-L1 preadipocytes from apoptosis through induction of insulin-like growth factors

Longo K. A., Kennell J. A., Ochocinska M. J., Ross S. E., Wright W. S., MacDougald O. A.
Year: 2002 • J Biol Chem 277: 38239-44


Regulation of Wnt signaling during adipogenesis

Bennett C. N., Ross S. E., Longo K. A., Bajnok L., Hemati N., Johnson K. W., Harrison S. D., MacDougald O. A.
Year: 2002 • J Biol Chem 277: 38239-44


Microarray analyses during adipogenesis: understanding the effects of Wnt signaling on adipogenesis and the roles

Ross S. E., Erickson R. L, Gerin I., DeRose P. M., Bajnok L., Longo K. A., Misek D. E., Kuick R., Hanash S. M., Atkins K. B., Andresen S.M., Nebb H. I., Madsen L., Kristiansen K., MacDougald O. A.
Year: 2002 • Mol Cell Biol 22:5989-99


Growth hormone regulates phosphorylation and function of CCAAT/enhancer-binding protein by modulating Akt and glycogen synthase kinase-3

Erickson, R. L., N. Hemati, S. E. Ross, and O. A. MacDougald.
Year: 2001 • J Biol Chem 276:16348-55


P300 coactivates the adipogenic transcription factor C/EBPα

Piwien-Pilipuk, G., D. V. Mater, S. E. Ross, O. A. MacDougald and J. Schwartz
Year: 2001 • J J Biol Chem 276(22): 19664-19671


Glycogen synthase kinase 3 is an insulin-regulated C/EBPα kinase

Ross, S. E., R. L. Erickson, N. Hemati, and O. A. MacDougald
Year: 1999 • Mol Cell Biol 19:8433-41


CCAAT/enhancer-binding protein beta (C/EBPβ) and C/EBPδ contribute to growth hormone-regulated transcription of c-fos

Liao, J., G. Piwien-Pilipuk, S. E. Ross, C. L. Hodge, L. Sealy, O. A. MacDougald, and J. Schwartz
Year: 1999 • J Biol Chem 274:31597-604


The role of C/EBP genes in adipocyte differentiation

Darlington, G. J., S. E. Ross, and O. A. MacDougald
Year: 1998 • J Biol Chem 273:30057-60


A role for the p38 mitogen-activated protein kinase/Hsp 27 pathway in cholecystokinin-induced changes in the actin cytoskeleton in rat pancreatic acini

Schafer, C., S. E. Ross, M. J. Bragado, G. E. Groblewski, S. A. Ernst, and J. A. Williams
Year: 1998 • J Biol Chem 273:30057-60


Signaling pathways through which insulin regulates CCAAT/enhancer binding protein alpha (C/EBPα) phosphorylation and gene expression in 3T3-L1 adipocytes. Correlation with GLUT4 gene expression

Hemati, N., S. E. Ross, R. L. Erickson, G. E. Groblewski, and O. A. MacDougald
Year: 1997 • J Biol Chem 272:25913-9